Download Toxicology of the Pancreas by Parviz M. Pour PDF

By Parviz M. Pour

ISBN-10: 0415320712

ISBN-13: 9780415320719

The elevated prevalence of pancreatic melanoma within the Western international and its grave analysis has ended in an urgency for learn during this sector. in the past the to be had info on toxicology of the pancreas has been few and fragmentary, scattered during the literature. A benchmark quantity, Toxicology of the Pancreas pulls jointly details during this ignored zone of toxicological examine and highlights primary examine played within the final ten years. Leaders within the box talk about very important constructions, the detoxing and toxification strategy on the mobile and sub-cellular point, the distribution of part 1 and section 2 drug-metabolizing enzymes and their function in pancreatic illness, and the position of vitamin and toxicants on pancreatic sickness. The e-book additionally covers the function of altered genes within the integrity of the pancreas and explores comparative toxicology in people and within the lab species utilized in trying out. Illustrated with histological, electron microscopical, and immunohistochemical codecs, this booklet presents a complete and novel presentation of organic and toxicological information. It stands by myself as a competent source of knowledge simply available to pros in several disciplines.

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Extra resources for Toxicology of the Pancreas

Example text

71 These results suggest that ductal precursors may diverge from a common acinar/islet precursor during early development of the pancreatic buds. 5 Regulation of Endocrine and Exocrine Differentiation Several lines of evidence point to a common progenitor cell for endocrine and acinar cells. All epithelium in the pancreatic buds express Pdx1 at early stages, but with cytodifferentiation acinar cell types lose high-level Pdx1 expression. Conversely, Ptf1a is only found in acinar cells of the adult pancreas, but Cre-loxP lineage tracing demonstrates that a large proportion of islet cells express Ptf1a at some point in their ontogeny.

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