Download Dompaminergic Neuron Transplantation in the Weaver Mouse by Lazaros C. Triarhou PDF

By Lazaros C. Triarhou

ISBN-10: 0585409501

ISBN-13: 9780585409504

ISBN-10: 1587060515

ISBN-13: 9781587060519

This publication is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
through genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single to be had laboratory version with a protracted disease that mimics Parkinson's disorder. Structural and useful features of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor telephone survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.

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Additional resources for Dompaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Neuroscience Intelligence Unit)

Example text

Chapter 6). In studies with mesencephalic grafts into a preformed surgical cavity and survival times of four to five months after transplantation,10,13,14 donor tissue was situated in the forebrain cavity, lying over the head of the caudate-putamen complex and contained an estimated 100-1000 TH immunoreactive neurons. Grafted TH immunoreactive neurons reached 10-20 µm in diameter. Dendrites and axons emanated from the neuronal somata, making the neuropil of the grafts appear rich with a dense network of TH-immunolabeled fibers.

Exploration of a hole-board matrix in nervous mutant mice. Brain Res 1985; 343:356-359. 121. Porsolt RD, Bertin A, Blavet N et al. Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity. Eur J Pharmacol 1979; 57:201-210. 122. Whishaw IQ, Dunnett SB. Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues. Behav Brain Res 1985; 18:11-29. 123. Wetts R, Moran T, Oster-Granite M et al.

Soc Neurosci Abstr 1990; 16:1138. 40. Triarhou LC, Tsoukalas LH. Clues to the pathogenesis of dopaminergic neuron degeneration in the weaver mouse midbrain. Exp Neurol 1999; 159:615. 41. Gaspar P, Ben Jelloun N, Febvret A. Sparing of the dopaminergic neurons containing calbindinD28k and of the dopaminergic mesocortical projections in weaver mutant mice. Neuroscience 1994; 61:293-305. Biology and Pathology of the Weaver Mutant Mouse 33 42. Bayer SA, Wills KV, Triarhou LC et al. Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice.

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