Download Cell Therapy for Brain Injury by David C. Hess PDF

By David C. Hess

ISBN-10: 3319150626

ISBN-13: 9783319150628

ISBN-10: 3319150634

ISBN-13: 9783319150635

Cell remedy for mind damage is an intensive exam of utilizing state of the art mobile treatment within the remedy of strokes and different tense mind accidents. This helpful e-book covers this area of interest subject intensive from uncomplicated stem mobilephone biology and rules of cellphone remedy via proposed mechanisms of motion of mobilephone remedy in stroke, pre-clinical facts in stroke types, ongoing scientific trials, imaging and monitoring of cells with MRI, neural stem cells in stroke and the "big pharma" standpoint of mobile treatment. every one bankruptcy is written via famous leaders in each one box, therefore supplying a wealth of workmanship. The breadth of this ebook makes it crucial analyzing for neuroscientists, stem mobile biologists, researchers or scientific trialists at pharmaceutical or biotechnology businesses. It additionally serves as an intensive creation for graduate scholars or post-doctoral fellows who wish to paintings in those fields.

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Extra resources for Cell Therapy for Brain Injury

Example text

To avoid this, strategies to minimize lung adhesion and improve homing of systemically introduced cells are used, including the use of vasodilators, reduction in number of cells administered, or different routes of administration. For example, an intra-arterial approach can bypass pulmonary circulation; intra-arterial transplantations resulted in superior delivery and sustained presence of stem cells in the ischemic brain compared to intravenous infusions [26]. However, an arterial approach may cause arterial occlusion, resulting in stroke, and is reportedly not superior to intravenous approach for recovery after stroke [26, 27].

After randomization, experimental procedures may not be blinded, as bone marrow sham aspiration should not be performed in control patients. A MSC dose equivalent to that used in animal studies (1 × 105–3 × 106 cells/ rat), and based on mean body weight, should be used. Patient selection should be based on severity and location of lesions, and time of application. , stromal cell-derived factor 1α) in the infarcted brain disappears. As all preclinical studies were conducted in animal models of middle cerebral artery occlusion, patients with middle cerebral artery territory (or anterior circulation) stroke should be selected.

11. Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, et al. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain. 2011;134(Pt 6):1790–807. Epub 2011/04/16. 12. Svensson J, Ghatnekar O, Lindgren A, Lindvall O, Norrving B, Persson U, et al. Societal value of stem cell therapy in stroke—a modeling study. Cerebrovasc Dis. 2012;33(6):532–9. Epub 2012/05/11. 13. Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA. Stem cell transplantation for ischemic stroke.

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