Download Casarett & Doull's Toxicology The Basic Science of Poisons, by Curtis Klaassen PDF

By Curtis Klaassen

The main depended on all-in-one evaluate of the biomedical and environmental elements of toxicology--NOW extra entire, up to date, and in complete color
The worlds top and such a lot authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever earlier than. Now in complete colour, and punctiliously revised, the 8th variation of Casarett & Doulls TOXICOLOGY: the elemental technology of toxins not just gives you a entire evaluate of the fundamental parts of toxicology, it bargains the main updated, revealing, and in-depth examine the systemic responses of poisonous substance to be had anywhere.
Combined with the newest considering through the fields greatest students plus sturdy insurance of basic rules, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the normal for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the elemental elements of toxicology featured in the course of the text
- elevated tables, illustrations, and different visuals are up to date with state of the art criteria that makes this version much more present and relevant
- NEW CHAPTERS contain «Toxic results of energy» and «Toxic results of Nanoparticles»

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Extra info for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition

Sample text

Beeson BB. Orfila—pioneer toxicologist. Ann Med Hist. 1930;2:68–70. Bernard C. Analyse physiologique des proprietes des systemes musculaire et nerveux au moyen du curare. C R Acad Sci (Paris). 1856;43: 325–329. Bryan CP. The Papyrus Ebers. London: Geoffrey Bales; 1930. Clendening L. Source Book of Medical History. New York: Dover; 1942. Gaddum JH. Pharmacology. 5th ed. New York: Oxford University Press; 1959. Garrison FH. An Introduction to the History of Medicine. 4th ed. Philadelphia: Saunders; 1929.

The term hypersensitivity is most often used to describe this allergic state, but allergic reaction and sensitization reaction are also used to describe this situation when preexposure of the chemical is required to produce the toxic effect (see Chap. 12). Once sensitization has occurred, allergic reactions may result from exposure to relatively very low doses of chemicals; therefore, population-based dose–response curves for allergic reactions have seldom been obtained. Because of this omission, some people assumed that allergic reactions are not dose-related.

12. , 1974; Levine, 1978; Uetrecht, 2007). The response observed is usually qualitatively similar to that observed in all individuals but may take the form of extreme sensitivity to low doses or extreme insensitivity to high doses of the chemical. , 1974). A classic example of an idiosyncratic reaction is provided by patients who exhibit prolonged muscular relaxation and apnea (inability to breathe) lasting several hours after a standard dose of succinylcholine. Succinylcholine usually produces skeletal muscle relaxation of only short duration because of its very rapid metabolic degradation by an enzyme that is present normally in the bloodstream called plasma butyrylcholinesterase (also referred to as pseudocholinesterase).

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