Download Analgesia by Christoph Stein, Christoph Stein PDF

By Christoph Stein, Christoph Stein

ISBN-10: 3540338225

ISBN-13: 9783540338222

This quantity makes an attempt to summarize the present kingdom of information on mechanisms underlying a number of the results of analgesics, their part impression profiles, and their symptoms and contraindications in medical use. It additionally provides insights into present efforts to find novel mechanisms underlying the new release of other varieties of soreness and the ensuing improvement of latest modulating compounds.

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Sample text

Stein (Pasternak 2004). Using radiolabeled agonists and antagonists different highaffinity binding sites were detected and termed as μ1 - and μ2 -receptor (Pasternak 2004). In vivo pharmacological studies proposed δ1 - and δ2 -receptor subtypes (Mattia et al. 1991) and κ1 -, κ2 , and κ3 -receptor subtypes (Attali et al. 1982). However, only three opioid receptor genes have been characterized so far. Subtypes may result from alternative processing, splice variants, or a combination of the two. Splicing of μ-receptor messenger RNA (mRNA) has been observed in a variety of species.

In Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Opioid Receptor Ligands and Sites of Action . Endogenous Ligands . . . . . . . Exogenous Ligands . . . . . . . . Sites of Action . . . . . . . . . Supraspinal and Spinal Sites .

49 49 49 49 50 50 51 51 51 52 52 . . . . . . . . . . . . . . . . . . . . . 32 C.

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