By Jacques Descotes
Lyon-RTH Laennec college of drugs, France. creation to key immunotoxicological matters. Considers the health and wellbeing outcomes of immunotoxicity and addresses the cutting-edge equipment used to discover and evaluation unforeseen immunotoxic results of xenobiotics, either preclinically and clinically. For undergraduate and graduate scholars. Hardcover, softcover additionally to be had.
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1997) are possible examples of xenobiotics with immunostimulating properties, even though the actual consequences on human health of the immunostimulation presumably associated with exposure to these compounds remain to be established. 5°C) with chills, arthralgias and malaise were described very early following the introduction of medicinal products with suspected or established 31 32 An Introduction to Immunotoxicology immunostimulating properties, such as glycan derivatives, Corynebacterium parvum, BCG, levamisole or poorly purified interferon preparations, into the clinical setting (Descotes, 1985a).
After a subsequent (but not necessarily the second) contact, sensitisation becomes patent, as a clinical reaction develops. To be sensitising, xenobiotics must comply with both the following prerequisites: • Xenobiotics must be foreign or ‘non-self’ to be sensitising, which is always so when xenobiotics are concerned, except for a limited number of medicinal products of human origin, such as biotechnologically-derived human insulin or growth hormone. • The molecular weight of xenobiotics must be large enough for them to be sensitising (or immunogenic), although no minimal requirement is established (but presumably above 5000 D or less for peptides because of the greater immunogenicity of peptidic bonds).
N. (1990) The complications of newer transplant antirejection drugs: treatment with cyclosporin A, OKT3, and FK506. Adv. Drug React. , 9, 123–155. , et al. (1980) Fatal disseminated BCG infection in an 18–year-old boy. Lancet, ii, 1332–1334. B. F. (1991) Environmental effects on the human immune system and the risk of cancer: facts and fears in the era of AIDS. Environ. Carcino. Ecotox. , 9, 155–206. NICHOLSON, V. C. (1994) Infectious complications in solid organ transplant recipients. Surg. Clin.